DemeTECH's Polyglactin 910 is a sterile, synthetic absorbable suture made from copolymers consisting of 90% glycolide and 10% L-lactide. Its chemical formula is represented as (C2H2O2)m(C3H4O2)n. Clinical studies indicate that two weeks post-operation, about 75% of the suture's original strength is retained, and by the fourth week, around 25% of its linear tensile strength remains.

This suture has been shown to be nonantigenic and causes minimal tissue reactivity during absorption. Available in both violet and colorless variants, Polyglactin 910 is coated to produce a smoother suture, enhancing its passage through tissue.

Benefits of Coated Polyglactin 910 sutures:

• Smooth passage through tissue.
• Accurate knot placement.
• Seamless knot tying.
• Reduced potential to irritate tissue.
• Enhanced tensile strength.
• Extended absorption duration.

Furthermore, clinical trials have shown that three weeks post-operation, DemeTECH's Polyglactin 910 sutures retain approximately 50% of their tensile strength.

Polyglactin 910 sutures, when implanted, can cause a minor tissue inflammation, a typical reaction to foreign bodies. This initial response is succeeded by the suture's encapsulation by connective tissue. The absorption process of Polyglactin 910 begins through hydrolysis, wherein the polymer breaks down into glycolic acid, which the body subsequently absorbs.

Key Points about Polyglactin 910 Sutures:

• They trigger a minimal acute inflammatory reaction in tissues.
• The suture gets gradually encapsulated by fibrous connective tissue post-implantation.
• The suture's progressive loss of tensile strength and its eventual absorption occur via hydrolysis. This results in the polymer degrading into either glycolic acid alone or a combination of glycolic and lactic acids. These acids are then metabolized by the body.
• The absorption process initially manifests as a decrease in tensile strength without a significant reduction in mass.
• The suture loses its original tensile strength by the 5th week post-implantation.
• Absorption of the Polyglactin 910 suture is essentially finished between 56 and 70 days after implantation.

Indications:

• Do not re-sterilize. Unused sutures should be discarded. Ensure storage at room temperature and avoid extended exposure to high temperatures.
• Prolonged contact with salt solutions, like in the urinary or biliary tracts, can lead to calculus formation.
• Users must be well-acquainted with surgical techniques using absorbable sutures before using Polyglactin 910 for wound closure due to potential variances in wound dehiscence risks.
• Adhere to standard surgical practices when addressing drainage and closure of infected or contaminated wounds.
• Polyglactin 910 might not be suitable for elderly, malnourished, debilitated patients, or those with conditions affecting wound healing.
• Given its absorbable nature, consider using non-absorbable sutures for sites prone to expansion or requiring additional support.
• Do not reuse. The design and materials are incompatible with standard sterilization methods. Reusing can lead to cross-contamination and compromised device safety and effectiveness.

Precautions:

• Properly handle Polyglactin 910 sutures, especially the needle, to avoid potential damage from needle holders. Familiarity with absorbable surgical sutures and their decreasing tensile strength is essential.
• In specific situations, such as orthopedic surgeries, external support immobilization might be required.
• Skin sutures left for over 7 days can cause irritation. They should be removed or trimmed as necessary.
• Care is required when handling sutures to prevent damage. Avoid crushing or crimping from surgical tools.
• Ensure knot security using standard surgical techniques. Depending on the surgical context and surgeon's expertise, additional throws might be necessary, especially with monofilaments.
• Polyglactin 910 may not be ideal for elderly or debilitated patients or those with delayed wound healing. Tissues with poor blood supply might reject the suture due to extended absorption.